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Abstract #21854 Published in IGR 10-3
Determinants of the optic cup to disc ratio in an Asian population: The Singapore Malay Eye Study (SiMES)
Amerasinghe N; Wong TY; Wong WL; Mitchell P; Shen SY; Loon SC; Saw SM; Foster PJ; Aung T; SiMES Study GroupArchives of Ophthalmology 2008; 126: 1101-1108
OBJECTIVE: To describe the distribution and determinants of the optic cup to disc ratio (CDR) in Malay adults in Singapore. METHODS: This population-based, age-stratified study examined 3280 Malay people aged 40 to 80 years in Singapore. Participants underwent a standardized interview and an ocular examination. A slitlamp examination measured the vertical dimensions of the disc and cup, excluding areas of peripapillary atrophy and the Elschnig scleral ring. RESULTS: Vertical CDR was recorded for 3228 right eyes and 3237 left eyes. The mean (SD) CDR was 0.40 (0.15) in both eyes. The CDR in the right eye increased with age (P < .001) and was greater in men vs women (age-adjusted CDR, 0.42 vs 0.39; P < .001). In multiple linear regression, significant determinants of greater CDR were increasing age, male sex, higher intraocular pressure (IOP), lower diastolic blood pressure, lower body mass index, and previous cataract surgery. Of these, higher IOP was the most important determinant of the CDR. After excluding 149 persons with glaucoma, male sex, higher IOP, lower diastolic blood pressure, lower body mass index, and diabetes mellitus were significant predictors of greater CDR. CONCLUSION: Greater vertical CDR was related to male sex, higher IOP, lower diastolic blood pressure, and lower body mass index.
Dr. N. Amerasinghe, Glaucoma Department, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore 168751, Singapore
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
