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Abstract #21878 Published in IGR 10-3
Ocular pulse amplitude in normal-tension and primary open-angle glaucoma
Stalmans I; Harris A; Vanbellinghen V; Zeyen T; Siesky BJournal of Glaucoma 2008; 17: 403-407
PURPOSE: (1) To investigate the relationship of ocular pulse amplitude (OPA) with intraocular pressure (IOP) and corneal thickness. (2) To evaluate OPA in patients with primary open-angle and normal-tension glaucoma (NTG). METHODS: Patients with NTG (n = 28), primary open-angle glaucoma (POAG) (n=19), and age-matched healthy controls (n = 22) underwent 2 consecutive Goldmann and dynamic contour tonometry measurements within 1 month. Central corneal thickness was also measured. A regression model was applied to compare OPA between the diagnostic groups. RESULTS: OPA increased with rising IOP (slope 0.026/0.033 and P = 0.002/< 0.0001 for Goldmann/Dynamic tonometry), whereas corneal thickness did not influence pulse amplitude measurements (slope-0.0017/-0.0013 and P = 0.11/0.21 after correction for Goldmann/Dynamic tonometry). In a multivariate model correcting for IOP and corneal thickness, OPA was reduced in patients with NTG (P = 0.014/0.017 corrected for Goldmann/Dynamic tonometry) or POAG (P = 0.015/0.014). CONCLUSIONS: OPA is reduced in normal-tension and POAG patients compared with healthy controls. OPA is influenced by IOP, but not by corneal thickness.
Dr. I. Stalmans, Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium. Ingeborg.stalmans@uzleuven.be
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
