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Abstract #22045 Published in IGR 10-4
Application of glaucoma probability score and Moorfields regression analysis in primary angl- closure glaucoma
Wu G; Li S; Xie C; Wang N; Zhai G; Wang XChinese Ophthalmic Research 2008; 26: 697-700
OBJECTIVE: Optic disc change is one of the main evidences of glaucoma. Two methods can be selected to used to the evaluation of optic disc using Heidelberg Retinal Tomograph (HRT). This study was to compare the diagnostic findings of the glaucoma probability score (GPS) of HRT with that of the Moorfields regression analysis (MRA) in primary angle-closure glaucoma (PACG). METHODS: 164 eyes of 164 patients with PACG and 120 eyes of 120 age- and sex-matched normal subjects were examined using HRT and MRA patterns of Heidelberg Retina Tomograph III. The diagnostic performances of GPS and MRA were evaluated. Logistic regression analyses was performed to evaluate the effect of covariates such as optic disc size and age on the classification outcomes of both the GPS and the MRA. RESULTS: Receiver operating characteristic curve (ROC) analysis showed that overall diagnostic performances of GPS and MRA were similar with under the ROC curve areas 0.75 and 0.70 respectively (P = 0.195). Complete agreement was analyzed using weighted Κ test with the kw = 0.251, u = 5.6 (P < 0.05). The factor of age, image quality and pattern standard deviation (PSD) and mean deviation (MD) appearred to not affect the classification outcome within group. Both GPS and MRA outcomes were affected by optic disc size. The odds of a positive classification (borderline or outside normal limits) increased by 10% (95% confidence interval [CI], 5%-14%) following 0.1 mm2 increase in optic disc area in GPS and MRA. CONCLUSION: The diagnosis of GPS and MRA has good consistence in PACG. GPS presents more prospective in management of glaucoma analysis because of without contour line placement. LA: Chinese
Dr. G. Wu, Department of Ophthalmology, Qingdao University Medical College, Qingdao 266021, China. wnltr@yahoo.com.cn
