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Abstract #22072 Published in IGR 10-4
Tumor necrosis factor α-308 gene polymorphism and pseudoexfoliation glaucoma
Tekeli O; Turacli ME; Egin Y; Akar N; Elhan AHMolecular Vision 2008; 14: 1815-1818
PURPOSE: To investigate the possible association between tumor necrosis factor alpha (TNF-α)-308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma. METHODS: One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a complete ophthalmic examination. TNF-α-308 was genotyped by polymerase chain reaction and restriction endonuclease analysis. RESULTS: We found a high prevalence of the G/G genotype in PEX glaucoma patients (OR = 2.88, 95% CI 1.15-7.20). The A polymorphic allele frequency was 3.2% in patients with PEX compared with 8.2% in controls (p = 0.023). CONCLUSIONS: Our results suggest that TNF-α-308 G/A genotype is not associated with PEX glaucoma. The -308G/A variant may be a possible protective factor against PEX.
Dr. O. Tekeli, Department of Ophthalmology, Ankara University School of Medicine, Ankara 06100, Turkey. oyatekeli@tr.net
