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Abstract #22149 Published in IGR 10-4
Application study of OCT in normal-tension glaucoma
Zhou X-Q; Zhong Y-SInternational Journal of Ophthalmology 2008; 8: 1587-1590
AIM: To investigate the thickness changes of the peripapillary retinal nerve fiber layer (RNFL) in patients with normal-tension glaucoma (NTG), suspected NTG patients and normal people and to evaluate the performance of OCT parameters for detection of NTG. METHODS: The OCT was used to examine the RNFL defects of 46 cases NTG (80 eyes), 43 cases of NTG suspects (80 eyes) and 40 cases of normal subjects (80 eyes). The Receiver operating characteristic curves were used to assess the performance of OCT. RESULTS: The OCT parameters of Avg. Thi, et al. were statistically different among the NTG patients, NTG suspects and normal subjects (F = 14.17-123.03, P < 0.05). The AUC of Avg. Thi with the highest veracity of diagnosis in OCT parameters in distinguishing NTG group and normal group was statistically higher than that in OCT parameter in distinguishing suspected NTG group and normal group (P < 0.01). CONCLUSION: The thickness of the peripapillary RNFL in patients with NTG becomes thinner than that of NTG suspects and normal subjects. OCT is helpful in diagnosis of NTG. OCT performs better in distinguishing NTG and normal subjects than in distinguishing NTG suspects and normal subjects. LA: Chinese
Dr. X.-Q. Zhou, Department of Ophthalmology, Ruijin Hospital of Medical College, Shanghai Jiaotong University, Shanghai 200123, China. Happymimi_2005@126.com
