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Abstract #22387 Published in IGR 10-4
Long-term visual prognosis of corneal and ocular surface surgery in patients with congenital aniridia
de la Paz MF; Alvarez de Toledo J; Barraquer RI; Barraquer JActa Ophthalmologica 2008; 86: 735-740
PURPOSE: To evaluate the long-term visual prognosis of corneal and ocular surface surgery in patients with congenital aniridia. METHODS: Retrospective comparative interventional case series on 88 eyes of 45 patients with congenital aniridia treated and/or operated on from 1956 to present. Corneal and ocular surface findings were identified and patients were classified into operated (group I) or not operated (group II). Long-term best-ever best-corrected visual acuity (BCVA), final BCVA and long-term δ BCVA (long-term best-ever BCVA - final BCVA) were recorded and compared between the two groups, and between the limbal transplant (LT) (group I-A) and the penetrating keratoplasty (PK) (group I-B) patients. Postoperative results were also compared. RESULTS: Limbal insufficiency was present in 58% of eyes and dense central corneal opacities were present in 27% of eyes. As a primary surgery, limbal allograft was performed in 10 eyes and PK in 13 eyes. The mean long-term follow-up times were 23 years in group I and 16 years in group II. The mean long-term δ BCVA was 0.032 in group I and 0.028 in group II. Comparisons of the VA means were insignificant (long-term best-ever, final BCVA and long-term δ BCVA). When comparing the LT and PK groups, mean long-term δ BCVA was 0.0328 in group I-A and 0.0382 in group I-B. Mean postoperative δ BCVA was 0.028 in group I-A and 0.048 in group I-B. We found no statistical significance between the LT and the PK groups as regards long-term postoperative BCVA results. CONCLUSION: Long-term visual prognosis does not differ whether or not the patient undergoes surgery for aniridic keratopathy. LT and PK have comparable results over 5 years of follow-up because of the eventual failure of transplanted allografts.
Dr. M.F. de la Paz, Barraquer Ophthalmology Centre, Barcelona, Spain. mpaz@barraquer.com