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Abstract #22407 Published in IGR 10-4
Detrimental effect of preservatives in eyedrops: implications for the treatment of glaucoma
Baudouin CActa Ophthalmologica 2008; 86: 716-726
Antiglaucoma medications are often associated with ocular adverse reactions such as dry eye, and burning or stinging sensations. These undesirable effects may lead to treatment discontinuation and reduced quality of life in patients with glaucoma. Antiglaucoma medications usually contain benzalkonium chloride (BAK) as a preservative. Animal studies, in vitro studies and in vivo experiments have demonstrated various adverse effects of BAK. Clinical studies have also shown an increased incidence of adverse events with BAK and have demonstrated that the withdrawal of preservatives reduces these effects. Collectively, these data suggest that preservative-free antiglaucoma treatments have clinically relevant benefits for patients.
Dr. C. Baudouin, Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, Paris, France. baudouin@quinze-vingts.fr
