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Abstract #22535 Published in IGR 11-1
Steroid-induced ocular hypertension in normal sheep
Gerometta R; Podos SM; Danias J; Candia OAInvestigative Ophthalmology and Visual Science 2009; 50: 669-673
PURPOSE: To determine whether the ovine eye develops elevation of intraocular pressure (IOP) in response to corticosteroid applied topically. METHODS: IOP was monitored by Perkins applanation tonometry in a group of 18 sheep receiving topically administered 0.5% prednisolone acetate in one eye (experimental), three times daily, for a period of 3 or four 4 weeks after the establishment of baseline IOP values. Perkins readings were converted to actual mmHg using a calibration curve derived from in vivo manometric measurements. IOP was monitored for an additional 1 to 3 weeks after discontinuation of corticosteroid treatment. RESULTS: Baseline IOP in normal sheep was 10.6±1.4 mmHg (mean ± SD; n=36 eyes). The IOP of the experimental eyes began to increase after 1 week of prednisolone treatment in all sheep and reached a peak 1 week later (27.5 mmHg experimental vs. 11.7 mmHg fellow, control eye; P<0.001). After the discontinuation of corticosteroid instillation, the IOP of the treated eyes declined to the baseline values over the course of 1 to 3 weeks. CONCLUSIONS: Ovine eyes exhibit a robust steroid-induced ocular hypertensive response, with 100% occurrence in this trial. The mechanisms of steroid-induced glaucoma may be related to those involved in primary open-angle glaucoma and could provide insight into primary open-angle and clues to its treatment.
Dr. R. Gerometta, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Del Nordeste, Corrientes, Argentina
Classification:
9.4.1 Steroid-induced glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
