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Abstract #22623 Published in IGR 11-1
Correlation between corneal and scleral thickness in glaucoma
Mohamed-Noor J; Bochmann F; Siddiqui MA; Atta HR; Leslie T; Maharajan P; Wong YM; Azuara-Blanco AJournal of Glaucoma 2009; 18: 32-36
See also comment(s) by Jost Jonas •
PURPOSE: To assess the correlation between central corneal thickness (CCT) and anterior scleral thickness (ST) in patients of primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), and ocular hypertension (OHT). PATIENTS AND METHODS: Consecutive patients with OHT, POAG, NTG, and normal individuals were recruited. CCT was measured by ultrasonic pachymetry, whereas ST was measured using ultrasonic biomicroscopy at the temporal quadrant, 2 mm posterior to the scleral spur. Investigators were masked to the diagnosis and CCT/ ultrasonic biomicroscopy data. Correlation between mean CCT and ST was analyzed. RESULTS: One hundred and twenty-four subjects (31 with OHT, 31 with POAG, 31 with NTG, and 31 normal individuals) were enrolled. The CCT (OHT 548.06±30.45 μm; POAG 519.39±42.95 μm; NTG 505.81±27.23 μm; controls 529.90±43.40 μm) was found to be thicker in patients with OHT than POAG (P=0.004) or NTG (P<0.01). There was also a difference in CCT between NTG and control eyes (P=0.012). The ST (OHT 755.03±69.58 μm; POAG 738.45±66.83 μm; NTG 708.74±71.58 μm; controls 724.45±73.27 μm) was thicker in the OHT group than in NTG patients (P=0.012). No significant difference in ST was found among other groups. Among subgroups, the correlation between CCT and ST was found only among the patients with NTG (r=0.440, P=0.013). However, no correlation was seen between CCT and ST in patients with OHT, POAG, and controls. CONCLUSIONS: There is a correlation between CCT and ST among the NTG group but no correlation was seen among OHT, POAG, and controls.
Dr. J. Mohamed-Noor, Department of Ophthalmology, Aberdeen Royal Infirmary and University of Aberdeen, Aberdeen, UK. JelinarMNoor@hotmail.com
Classification:
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
2.3 Sclera (Part of: 2 Anatomical structures in glaucoma)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)