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Abstract #22676 Published in IGR 11-1
Corneal penetration into rabbit aqueous humor is comparable between preserved and preservative-free tafluprost
Pellinen P; Lokkila JOphthalmic Research 2009; 1: 118-122
BACKGROUND: Some studies have shown that benzalkonium chloride (BAK), a preservative used in antiglaucoma medications, can increase corneal permeability by acting as a penetration enhancer. Tafluprost is a new prostaglandin F2α analog in clinical use for the treatment of ocular hypertension and glaucoma. METHODS: This study evaluated the corneal penetration of preservative-free tafluprost 0.0015% eye drops and tafluprost 0.0015% eye drops preserved with 0.01% BAK into the aqueous humor of rabbits. RESULTS: After the administration of a single topical dose (30 μl), the maximum concentrations at 45 min of tafluprost acid in aqueous humor were 4.50 ng/ml for preservative-free tafluprost and 3.99 ng/ml for preserved tafluprost. The area under the concentration-time curves from 45 min to 3 h was 5.14 ng h/ml for the preservative-free formulation and 4.54 ng h/ml for the preserved formulation. CONCLUSIONS: These data indicate that BAK does not affect the corneal penetration of tafluprost into the rabbit aqueous humor.
Dr. P. Pellinen, Santen Oy, Tampere, Finland. Pertti.pellinen@santen.fi
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.4 Prostaglandins (Part of: 11 Medical treatment)