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Abstract #22731 Published in IGR 11-1
Interpretation of the Humphrey Matrix 24-2 test in the diagnosis of preperimetric glaucoma
Choi JA; Lee NY; Park CKJapanese Journal of Ophthalmology 2009; 53: 24-30
PURPOSE: To define the diagnostic precision of the Humphrey Matrix 24-2 test and to determine a clinically applicable cutoff criterion for the inclusion of preperimetric glaucoma. METHODS: Eyes with preperimetric glaucoma (99 eyes) were defined as having normal standard automated perimetry (SAP) results and a glaucomatous optic nerve head, along with one or more optical coherence tomography (OCT) parameters flagged as <0.05 or a retinal nerve fiber layer (RNFL) defect on red-free fundus photographs. Normal controls (122 eyes) were defined as having a normal optic disc and RNFL with normal SAP. Receiver-operating characteristic (ROC) curves were constructed to determine the best-discriminating parameter of the frequency-doubling technology (FDT) Matrix. The sensitivity, specificity, and hit ratio of all available criteria were calculated from the FDT Matrix. RESULTS: Pattern standard deviation (PSD) showed a larger area under the ROC curve (AUC) (0.767) than mean deviation (MD) (0.619). A pattern deviation plot (PDP) analysis by modified Anderson criteria showed the highest discriminating power, with a sensitivity of 75.76%, followed by a PSD cutoff value of 3.14 dB (sensitivity, 73.74%). CONCLUSIONS: FDT Matrix seems to be a valuable clinical tool in the detection of preperimetric glaucoma. Among the parameters of the FDT Matrix, PDP analysis by modified Anderson criteria may provide a reliable cutoff criterion.
Dr. J.A. Choi, Department of Ophthalmology and Visual Sciences, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Classification:
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
