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Abstract #22802 Published in IGR 11-1
Long-term study of nipradilol ophthalmic solution in patients with normal-tension glaucoma
Yukawa E; Nitta N; Taketani F; Matsuura T; Morishita K; Hara YNippon Ganka Gakkai Zasshi 2008; 112: 994-998
PURPOSE: We investigated the long-term clinical effects of a nipradilol ophthalmic solution on normal-tension glaucoma. METHODS: Among normal tension glaucoma patients who consulted the Nara Medical University Hospital or 2 affiliated hospitals between November 2001 and August 2002, we prospectively examined intraocular pressure-decreasing effects, the deterioration of visual field defects, and the appearance of side effects in 46 patients who underwent single therapy with a nipradilol ophthalmic solution. We evaluated intraocular pressure at 6-month intervals. The deterioration of visual field defects was assessed based on a 3-dB or more decrease in the mean deviation measured using the Humphrey Field Analyzer 30-2 program. RESULTS: The 60 months intraocular pressure value after administration of nipradilol ophthalmic solution was significantly lower than the pretreatment value. The deterioration of visual field defects was examined using the Kaplan-Meier life table. The survival rate after 60 months was 82.4%. In 4 of the 46 patients, administration of the nipradilol ophthalmic solution was discontinued due to side effects. CONCLUSION: Long-term therapy with a nipradilol ophthalmic solution may be useful for treating normal-tension glaucoma. LA: Japanese
Dr. E. Yukawa, Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara-shi, Nara-ken 634-8522, Japan. Y-eiichi@mrh.biglobe.ne.jp
Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
