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Abstract #22902 Published in IGR 11-1

The expression of connective tissue growth factor in rabbit subconjunctival tissue wound healing

Yao L; Wang D; Bai H; Jin R
Chinese Ophthalmic Research 2008; 26: 837-840

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OBJECTIVE: Connective tissue growth factor (CTGF) is one of the most important factors in tissue wound healing. This study was designed to evaluate the role of CTGF in subconjunctival tissue wound healing. METHODS: Operation was performed on latenal eyes of 15 New Zealand rabbits, and the fellow eyes without operation were as controls. Rabbits were killed on day 1, 5 and 9 after operation. Conjunctiva and subconjunctiva tissue was harvested for histopathological and immunochemical examination under the light microscope. The expressions of CTGF and GAPDH were detected by semiquantitative reverse transcription polymerase chain reaction (RT-PCR). RESULTS: Immunohistochemistry positive stain showed the brown-yellow particles in the cytoplasm. Positive expression of CTGF in fibroblasts was enhanced 1 day after surgery in comparison with control eyes. In 5 days after surgery, the stain of CTGF was stronger obviously than 1 day group. Nine days later, the stain intensity of CTGF was weakened but was still stronger than normal eye. RT-PCR results indicated that CTGF mRNA was up-regulated 1 day and peaked in 5 days and began to descend in 9 days after surgery but was still higher than the control eyes, showing a statistically significant difference (P < 0. 01). CONCLUSION: During the progress of rabbit subeonjunctival tissue wound healing, the expression of CTGF increases in both protein and mRNA levels. It suggests that inhibition of CTGF synthesis may have a preventing effect on bleb failure and improving effect on glaucoma filtration surgery. LA: Chinese

Dr. L. Yao, Department of Ophthalmology, Yidu Central Hospital of Weifang City, Weifang 262500, China

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Classification:

12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)

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