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Abstract #22906 Published in IGR 11-1
Correlation analysis of GDxVCC parameters and visual field indices in early open-angle glaucoma
Zhang Q; Xia X; Wang P; Yang C; Zhou MChinese Ophthalmic Research 2008; 26: 860-864
OBJECTIVE: GDxVCC system uses the birefringent properties of the retinal nerve fiber layer (RNFL) to estimate its thickness. Experimental and clinical studies have demonstrated that the GDxVCC has high sensitivity and specificity in the glaucomatous diagnosis, but the correlation between perimetry and GDxVCC measurement is still underinvestigation. The purpose of this study was to evaluate the relationship between GDxVCC parameters and standard automated perimetry (SAP) indices. METHODS: Forty-two eyes from 21 normal subjects, 98 eyes of 50 individuals with suspected open-angle glaucoma and 84 eyes from 64 patients with early open-angle glaucoma were included in the study and examined with GDxVCC and SAP. The correlation between GDxVCC parameters and SAP indices was analyzed with Pearson's correlation and described with scatter plot. RESULTS: Between GDxVCC parameters and SAP indices in open-angle glaucoma, all RNFL parameters showed positive correlation with mean deviation(MD) of SAP (r = 0. 347 -0. 509, P <0. 05 ) except a negative correlation was seen in nerve fiber index (NFT) (r = -0. 461, P <0. 05). NFI was positive correlated with pattern standard deviation(PSD) (r = 0. 238, P < 0. 05), and TSNIT standard deviation was not correlated with PSD, and other RNFL parameters were negative correlation with PSD of SAP (r = - 0. 314 -- 0. 268, P < 0. 05). A statistically significant correlation was not demonstrated in healthy or suspected subjects (P > 0. 05). CONCLUSION: There is correlation between most GDxVCC parameters and perimetry indices in early open-angle glaucoma, but not in normal and suspected subjects. LA: Chinese
Dr. Q. Zhang, Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410078, China
Classification:
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.9.1.2 Confocal Scanning Laser Polarimetry (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)