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Abstract #22909 Published in IGR 11-1
Tissue transglutaminase and glaucoma
Jin R; Wang DChinese Ophthalmic Research 2008; 26: 795-797
Tissue transglutaminase (tTG), one of transglulaminases, is a multifunctional calcium-dependent enzyme. It widely exists in most cells and tissues of body. It can catalyzes the cross-linking of proteins and takes part in many physiologic and pathologic processes, such as growing of cells, adhering of cells, apoptosis, signal transduction and so on. Presently, it is found that tTG also plays an important role in the pathogenesis of primary open angle glaucoma and scarring after glaucoma filtering surgery. The relationships of tTG and glaucoma, tTG and filtering surgey, tTG and extracellular matrix (ECM) were reviewed. LA: Chinese
Dr. R. Jin, Department of Ophthalmology, Central Hospital of Handan City, Handan 056001, China
Classification:
3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)