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Miscellaneous (25)

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Abstract #23025 Published in IGR 11-1

Measurements of the filtering bleb area and intraocular pressure following subconjunctival injection of CTGF antibody after glaucoma filtration surgery in a rabbit model

Wang J-M; Hui N; Fan Y-Z; Xiong L; Sun N-X
International Journal of Ophthalmology 2008; 8: 2005-2007

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AIM: To study the role of connective tissue growth factor (CTGF) antibody in inhibiting bleb scarring after glaucoma filtration surgery (GFS) in a rabbit model. METHODS: GFS was performed on both eyes in 5 rabbits. One eye of each rabbits was chosen randomly as antibody group and received subconjunctival injection of 0.1mL CTGF antibody (50mg/L) when GFS finished and on 3 days after GFS. The other eye of each rabbit as control group was received subconjunctival injection of 0.1mL phosphate buffered saline (PBS) at the same time as antibody group. On postoperative 1, 3, 5, 7, 10 and 14 days, the appearance of filtrating blebs was observed under slit lamp, their areas and the intraocular pressure (IOP) were measured with micrometer and applanation tonometer, respectively. RESULTS: On postoperative 7, 10 and 14 days, areas of filtrating blebs in antibody group were all larger than that in control group (P < 0.05) and IOPs of antibody group were lower than that of control group(P < 0.05). CONCLUSION: Subconjunctival injection of CTGF antibody can maintain larger bleb area and lower IOP after GFS in rabbit. This indicates that CTGF antibody is most likely to be a novel agent to prevent excessive scarring following GFS. LA: Chinese

Dr. J.-M. Wang, Department of Ophthalmology, Hospital of Xi'an Jiaotong University, Xi'an 710004 Shaanxi Province, China. xajdwjm@163.com

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Classification:

12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)

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