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Abstract #23513 Published in IGR 11-2
Mean target intraocular pressure and progression rates in chronic angle-closure glaucoma
Liza Sharmini AT; Yuen Shi Yin N; Shi-Huang Lee S; Jackson AL; Stewart WCJournal of Ocular Pharmacology and Therapeutics 2009; 25: 71-75
PURPOSE: The aim of this study was to evaluate risk factors for progression in chronic angle-closure glaucoma (CACG) patients. METHODS: A retrospective cohort of patient records in East Asia were evaluated for risk factors associated with progressive optic-disc and visual-field loss. There were 101 CACG patients with 5 years of follow-up. RESULTS: Seventy-one percent (71%) of patients with intraocular pressures (IOP) of >22 mmHg progressed, whereas 26% of patients with IOPs of 13-21 mmHg progressed, and 0% of patients with IOPs of <12 mmHg progressed. The mean IOP was 16.6 (plus or minus) 3.4 mmHg in the stable group and 18.8 (plus or minus) 3.5 mmHg in the progressed group (P = 0.007). The highest average peak IOP was 23.2 (plus or minus) 6.3 mmHg in the stable group and 26.5 (plus or minus) 6.5 mmHg in the progressed group (P = 0.03). Generally, patients whose standard deviation of IOP was <2 mmHg (12% progressed) were more often stable, compared to those who were >3 mmHg (33% progressed). A multivariate regression analysis was positive for mean IOP as a clinically important risk factor for progression. CONCLUSIONS: IOP reduction in CACG patients may help prevent progressive visual-field and optic-disc damage.
W. C. Stewart. Pharamaceutical Research Network, LLC, 5430 LBJ Freeway, Dallas, TX 75240, United States. info@prnorb.com
Classification:
9.3.2 Chronic primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
6.20 Progression (Part of: 6 Clinical examination methods)
