advertisement
Abstract #23529 Published in IGR 11-2
TNF-α-308 G>A and -238 G>A polymorphisms are not major risk factors in Caucasian patients with exfoliation glaucoma
Mossbock G; Renner W; El-Shabrawi Y; Faschinger C; Schmut O; Wedrich A; Zimmermann C; Weger MMolecular Vision 2009; 15:- 518-522
PURPOSE: TNF-α has been suggested to participate in the pathogenesis of exfoliation glaucoma (XFG). The purpose of the present study was to investigate a hypothesized association between two common functional polymorphisms in the promoter region of the TNF-α gene (TNF-α -308 G>A, rs1800629, and TNF-α -238 G>A, rs361525) and the presence of XFG in a Caucasian population. METHODS: The present case-control study comprised 408 participants (204 patients with XFG and 204 control subjects). Control subjects were matched for age and sex. Genotypes of the TNF-α -308 G>A and TNF-α-238 G>A polymorphisms were determined by polymerase chain reaction (restriction fragment length polymorphism). RESULTS: No significant differences regarding genotype distribution or allelic frequencies were found between patients and control subjects (p>0.025). The presence of the TNF-α-308 G-allele was associated with an insignificant odds ratio of 0.98 (95% confidence interval [CI]: 0.66-1.46; p=0.99) while the presence of the TNF-α-238 G-allele was associated with an insignificant odds ratio of 0.64 (95% CI: 0.33-1.23; p=0.25). CONCLUSIONS: Our data suggest that both the TNF-α-308 G>A and the TNF-α-238 G>A polymorphisms are unlikely to be major risk factors for XFG in an European population of Caucasian descent.
G. Mossbock. Department of Ophthalmology, Medical University Graz, Auenbruggerplatz 4, 8036 Graz, Austria. g.mossboeck@medunigraz.at
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
