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Abstract #23616 Published in IGR 11-2
Signal transduction pathways and their targeting mediators in scarring after filtration surgery
Fan F; Duan X-CInternational Journal of Ophthalmology 2009; 9: 542-545
A major cause of the failure in the filtration surgery of glaucoma lies in the postoperative scarring process. The transdifferentiation of fibroblasts to myofibroblasts is an "activated" fibroblast phenotype with increased synthesis of extracellular matrix proteins. The function of many cellular factors is a crucial step in wound healing and scarring and is required for subsequent tissue remodeling. Via TGF-β/Smad, Rho-ROCK, MAPK and NF-(kappa)B signal transduction pathways, many cytokines mediate the scarring process. It is possible to prevent the process by making use of methods such as RNA inference to regulate of some key targets, such as Smad, ROCK, P38MAPK. In this review, we summarized the primary signal transduction pathways in scarring after filtration surgery, and some targeting mediators. LA: Chinese
X.-C. Duan. Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha 410011 Hunan Province, China. duanxchu@yahoo.com.cn
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)