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Abstract #23727 Published in IGR 11-2
Species variation in biology and physiology of the ciliary epithelium: similarities and differences
Do CW; Civan MMExperimental Eye Research 2009; 88: 631-640
Glaucoma is a leading cause of irreversible blindness worldwide. Lowering intraocular pressure (IOP) is the only strategy documented to delay the appearance and retard the progression of vision loss. One major approach for lowering IOP is to slow the rate of aqueous humor formation by the ciliary epithelium. As discussed in the present review, the transport basis for this secretion is largely understood. However, several substantive issues are yet to be resolved, including the integrated regulation of secretion, the functional topography of the ciliary epithelium, and the degree and significance of species variation in aqueous humor inflow. This review discusses species differences in net secretion, particularly of Cl(-) and HCO(3)(-) secretion. Identifying animal models most accurately mimicking aqueous humor formation in the human will facilitate development of future novel initiatives to lower IOP.
School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Classification:
2.9 Ciliary body (Part of: 2 Anatomical structures in glaucoma)
2.6.1 Production (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)