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Abstract #23728 Published in IGR 11-2

Stem cells in the trabecular meshwork: present and future promises

Kelley MJ; Rose AY; Keller KE; Hessle H; Samples JR; Acott TS
Experimental Eye Research 2009; 88: 747-751

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Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.

Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA. kelleyma@ohsu.edu

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Classification:

2.5.1 Trabecular meshwork (Part of: 2 Anatomical structures in glaucoma > 2.5 Meshwork)
2.17 Stem cells (Part of: 2 Anatomical structures in glaucoma)

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