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Abstract #23872 Published in IGR 11-2
Dietary Tocopherol Supplementation after Trabeculectomy and Phacotrabeculectomy: Double-Blind Randomized Placebo-Controlled Trial
Goldblum D; Meyenberg A; Mojon D; Tappeiner C; Frueh BEOphthalmologica 2009; 223: 226-230
PURPOSE: The vitamin E compound alpha-tocopherol inhibits fibroblast growth in vitro. To evaluate its potential benefit in preventing failure of glaucoma filtration surgery, we prospectively investigated the outcome of filtering surgery with postoperative dietary alpha-tocopherol supplementation. PATIENTS AND METHODS: Thirty-nine patients (39 eyes) with primary open-angle glaucoma or pseudoexfoliative glaucoma were randomly assigned to two post-(phaco)-trabeculectomy treatment groups. Daily oral intake of 300 mg alpha-tocopheryl-acetate (absorbed as alpha-tocopherol in the intestine) for 2 months was compared to a placebo preparation in a double-blind trial. The follow-up time was 1 year. Success was defined as intraocular pressure (IOP) ≤18 mm Hg with no medication, no needling revision, and no subconjunctival injection. RESULTS: In the tocopherol group, the relative risk for trabeculectomy failure decreased from 1.58 at 2 weeks (p = 0.95) to 1.0 at 1 year. Success rates (67-90%) and IOP reduction (mean 39 to 53%) were statistically comparable in the two groups. Considering postoperative complications, no relevant differences were found. DISCUSSION: Trabeculectomy and phacotrabeculectomy outcome did not show any differences between alpha-tocopherol-supplemented patients and the placebo group.
Department of Ophthalmology, University of Bern, Inselspital, Bern, Switzerland.
Classification:
12.8.1 Without tube implant (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
12.14.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.14 Combined cataract extraction and glaucoma surgery)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
