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Abstract #23899 Published in IGR 11-2

Optic disc cupping after optic neuritis evaluated with optic coherence tomography

Rebolleda G; Noval S; Contreras I; Arnalich-Montiel F; García-Perez JL; Muñoz-Negrete FJ
Eye 2009; 23: 890-894

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PURPOSE: To determine whether the optic disc experiences cupping after an episode of optic neuritis as assessed by optical coherence tomography (OCT). METHODS: A total of 50 patients with unilateral optic neuritis and 50 age- and sex-matched controls were studied. A complete examination, including visual acuity (VA), visual fields, and OCT scanning of the optic nerve head was performed. Mean cup-to-disc (C/D) ratios in the affected eyes were compared with fellow and control eyes. RESULTS: Mean C/D area ratio (CDAR), C/D vertical ratio (CDVR), and C/D horizontal ratio (CDHR) were significantly larger in the affected eyes compared to fellow (P<0.001) and control eyes (P<0.05). The asymmetry in CDAR, CDVR, and CDHR between both eyes in the patients with optic neuritis was equal to or greater than 0.2 in 24, 28, and 30% respectively. A significant inverse correlation was found between the C/D ratios asymmetry and retinal nerve fibre layer (RNFL) thickness (P<0.05). CONCLUSION: A significant increase in C/D ratio can be detected by OCT after unilateral optic neuritis, inversely correlated with RNFL thickness, and VA.

Ophthalmology Department, Glaucoma Unit, Hospital Ramón y Cajal, Madrid, Spain. grebolleda@telefonica.net

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Classification:

10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)

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