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Abstract #24098 Published in IGR 11-3
Gene therapy targeting glaucoma: where are we?
Liu X; Rasmussen CA; Gabelt BT; Brandt CR; Kaufman PLSurvey of Ophthalmology 2009; 54: 472-486
In a chronic disease such as glaucoma, a therapy that provides a long lasting local effect with minimal systemic side effects, while circumventing the issue of patient compliance, is very attractive. The field of gene therapy is growing rapidly and ocular applications are expanding. Our understanding of the molecular pathogenesis of glaucoma is leading to greater specificity in ocular tissue targeting. Improvements in gene delivery techniques, refinement of vector construction methods, and development of better animal models combine to bring this potential therapy closer to reality.
Dr. X. Liu, Department of Ophthalmology and Ophthalmic Laboratories, West China Hospital, Sichuan University, Chengdu, China
Classification:
11.9 Gene therapy (Part of: 11 Medical treatment)
