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Abstract #24409 Published in IGR 11-3
Sustained elevation in intraocular pressure associated with intravitreal bevacizumab injections
Kahook MY; Kimura AE; Wong LJ; Ammar DA; Maycotte MA; Mandava NOphthalmic Surgery Lasers and Imaging 2009; 40: 293-295
This retrospective case series reports sustained elevation of intraocular pressure (IOP) after single or repeated intravitreal injections of bevacizumab (Avastin; Genentech, San Francisco, CA) for wet age-related macular degeneration (AMD). All six cases experienced significant and sustained elevation in IOP after single or repeated intravitreal injections of bevacizumab. Initiation or advancement of IOP-lowering therapy was required in all cases. The results support the need for further studies investigating the incidence of this potential side effect and the need for close long-term surveillance of IOP after injection of bevacizumab, particularly in patients with glaucoma or suspected glaucoma. Future in vitro and in vivo studies are needed to better understand the reasons for this observed phenomenon.
Dr. M.Y. Kahook, Rocky Mountain Lions Eye Institute, University of Colorado at Denver, Mail Stop F731, 1675 N. Ursula St., Aurora, CO 80045, USA
Classification:
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
