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Abstract #24427 Published in IGR 11-3
Dorzolamide/timolol combination versus latanoprost in the treatment of open-angle glaucoma: A systematic review
Ai Shan MLKM; Hadier JChinese Journal of Evidence-Based Medicine 2009; 9: 350-354
OBJECTIVE: To assess the efficacy and safety of a dorzolamide/timolol combination versus latanoprost in the treatment of open-angle glaucoma. METHOD: We searched for randomized control trials concerning a dorzolamide/ timolol combination versus latanoprost in the treatment of open-angle glaucoma,in electronic databases , and hand- searched some related journals. The quality was evaluated and meta-analysis was conducted using the software RevMan 5.0. RESULTS: Six randomized control trials involving 361 patients and 361 eyes were identified. The Meta-analysis showed that at the end of study, there was a statistically significant difference between the two study groups with WMD -0.49, and 95%CI -1.06 to 0.07 ( P=0.09) in lowering intraocular pressure; there was no statistically significant difference between the two groups with WMD 1.43 and 95%CI 0.49 to 4.21 (P=0.53); and there was no statistically significant differences between the two groups with WMD 0.40 and 95%CI 0.13 to 1.26 (P=0.12) in incidence of headache. CONCLUSION: Compared with latanoprost, dorzolamide-timolol combination have increased efficacu in lowering intraocular pressure (IOP).If we want a more reliable result ,we need a large number of multi-centre,double-blinded randomized control trials.
Dr. M.L.K.M. Ai Shan, Department of Ophthalmology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Classification:
11.13.2 Betablocker and carbon anhydrase inhibitor (Part of: 11 Medical treatment > 11.13 Combination therapy)
11.4 Prostaglandins (Part of: 11 Medical treatment)
