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1 General aspects (0)   1.1 Epidemiology (7)   1.2 Population genetics (0)   1.3 Pathogenesis (4)   1.4 Quality of life (8)   1.5 Glaucomas as cause of blindness (5)   1.6 Prevention and screening (8) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (6)   2.2 Cornea (14)   2.3 Sclera (3)   2.4 Anterior chamber angle (3)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (6)     2.5.2 Schlemms canal (2)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (4)       2.6.2.2 Uveoscleral (1)     2.6.3 Compostion (0)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (3)   2.9 Ciliary body (6)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (0)   2.13 Retina and retinal nerve fibre layer (21)   2.14 Optic disc (17)   2.15 Optic nerve (5)   2.16 Chiasma and retrochiasmal central nervous system (4)   2.17 Stem cells (1)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (1)   3.2 Electron microscopy (2)   3.3 Immunohistochemistry (3)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (2)     3.4.2 Gene studies (16)   3.5 Molecular biology incl. 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Miscellaneous (31)

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Abstract #24533 Published in IGR 11-4

The histopathological examination of mice tissues after the treatment with new synthesized prostamides with antiglaucoma action

Udeanu DI; Enache M; Mihele D; Cocu F
Farmacia 2009; 57: 315-320

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Prostamides are nowadays considered as the most effective drugs used for the long term treatment of primary open angle glaucoma. New prostamides with potential antiglaucoma action were synthesized within the Department of Biosynthesis of Natural Products from the National Institute for Chemical and Pharmaceutical Research and Development, Bucharest. The current research is part of the preliminary toxicological studies and tries to assess the possible histopathological modifications of mice tissues after the treatment with new synthesized prostamides.

D.I. Udeanu. University of Medicine and Pharmacy Carol Davila Bucharest, Faculty of Pharmacy, Department of Clinical Laboratory and Food Safety, Traian Vuia 6, Bucharest 020956, Romania. denisaudeanu@gmail.com

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Classification:

11.4 Prostaglandins (Part of: 11 Medical treatment)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
3.2 Electron microscopy (Part of: 3 Laboratory methods)

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