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Abstract #24562 Published in IGR 11-4
Lead Accumulation as Possible Risk Factor for Primary Open-Angle Glaucoma
Yuki K; Dogru M; Imamura Y; Kimura I; Ohtake Y; Tsubota KBiological Trace Element Research 2009; 132: 1-8
See also comment(s) by Robert Ritch & Anzhelika Vaccaro •
We evaluated the association between hair lead concentrations and primary open-angle glaucoma. Ninety-eight Japanese patients (40 males, 58 females; average age 57.6(plus or minus)10.8 years) with primary open-angle glaucoma and control subjects (131 males, 114 females; average age 56.0(plus or minus)12.8 years) were recruited in this study. Hair lead levels were measured by inductively coupled plasma mass spectrometry. Hair lead concentrations between primary open-angle glaucoma and control groups were compared using Mann-Whitney U test. As a subgroup analysis, we compared hair lead concentrations between low-tension glaucoma, high-tension glaucoma, and control groups using one-factor analysis of variance. Lead accumulation levels were significantly higher in the female subjects with primary open-angle glaucoma compared to the control group (P=0.03). Lead accumulation levels were significantly higher in female patients with low intraocular pressure compared to control group 2 (P=0.02). A higher hair lead level, which reflects the total body burden of lead, was observed to be associated with primary open-angle glaucoma in females especially with low-tension glaucoma. Accumulation of lead may be an unrecognized risk factor of non-pressure-dependent glaucomatous optic neuropathy.
K. Yuki. Department of Ophthalmology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan. glaucoma.keio@gmail.com
Classification:
15 Miscellaneous
1.3 Pathogenesis (Part of: 1 General aspects)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
