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Abstract #24569 Published in IGR 11-4
Histological biocompatibility of a stainless steel miniature glaucoma drainage device in humans: A case report
De Feo F; Jacobson S; Nyska A; Pagani P; Traverso CEToxicologic Pathology 2009; 37: 512-516
The purpose of this study was to evaluate the histological biocompatibility of a stainless steel miniature glaucoma drainage device. Twenty-four months before death due to heart failure, this seventy-three-year-old female patient underwent filtration surgery for primary open-angle glaucoma uncontrolled in the right eye. The device was implanted at the limbus under a scleral flap. For histopathological evaluation, two corneoscleral specimens were embedded in methacrylate blocks sectioned to a thickness of 50 microns, polished and stained with periodic acid schiff. Some sections included a longitudinal cross-section of the implant. At the interface between the spur and the flange of the device and the cornea, there was a small shoulder of fibrous tissue. A thin, fibrous capsule covered the remainder of the body of the device up to the distal tip. No inflammatory cells occurred within the fibrous capsule. No material or blockage was noted within the lumen. Our results support the biological inertness of the device.
C. E. Traverso. Director of Glaucoma Service, Centro di Ricerca Clinica e Laboratorio per Il Glaucomae la Cornea, Di.N.O.G., University of Genova, Italy. mc8620@mclink.it
Classification:
12.8.2 With tube implant or other drainage devices (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
