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Abstract #24615 Published in IGR 11-4
The measurement and analysis of anterior chamber change in primary angle-closure glaucoma
Wang H; Lin D; Zhang SChinese Ophthalmic Research 2009; 27: 706-709
Objective: Many studies have proved that the transient change of anterior chamber depth (ACD) can cause the attack of primary angle closure glaucoma. The change of anterior convexity of iris during the dark-room prone test is the cause of the attack eyes. Present study aimed to observe and quantitatively analyse the extent of forward movement of lens-iris diaphragm and change of iris contour in glaucomous attack eyes during dark-room prone test. Methods: Photos of anterior chambers were taken in 15 glaucomous attack eyes (13 cases) and 15 eyes with negative shallow anterior chambers (15 age-matched subjects) during the dark-room prone test by self-made dynamic camera and measurement system. The parameters of lens were measured using A scan ultrasonography, and ultrasound biomicroscope (UBM) images of the attack eyes were also analysed. The forward moving value was culculated by the difference of ACD between before and after dark-room prone test, and the ratio of ACD before and after dark-room prone test was as the dynamic ratio of anterior chamber. Written informed consent was obtained from all the subjects in this trial before any study protocol. Results: No statistically significant differences were found in ACD value before or after dark-room prone test, ACD difference value and ACD ratio between attack eyes and negative eyes(t = 0.216, 0.194, 0.081, -0.071; P > 0.05 respectively). There was no obvious difference in iris radium between attack eyes and negative eyes before test(t = - 1.155, P = 0.220). However, the difference in iris radium was found between attack eyes and negative eyes after test(t = -2.267, P = 0.022). The significant smaller iris radium value was seen after test than before test in attack eyes (t = 6.265, P = 0.000). There was a statistically significant difference in lens thickness and lens thickness/axial length ratio between attack eyes and negative eyes (P < 0.01) but no in axial length (P > 0.05) and corneal diameter (P > 0.05). Conclusion: The change of the anterior convexity of iris in attack eyes during the dark-room prone test is more dominant than that in negative ones. Some special anatomical parameters are measured in attack eyes using A scan ultrasonograph and UBM. The comprehensive analysis of dynamic changes of static anatomical characters offers an useful clue for diagnosis of primary angle-closure glaucoma. LA: Chinese
H. Wang. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. dlinoph@hotmail.com
Classification:
6.12 Ultrasonography and ultrasound biomicroscopy (Part of: 6 Clinical examination methods)
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
