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Abstract #24633 Published in IGR 11-4
Acetazolamide influences ocular pulse amplitude
Zinkernagel MS; Ebneter AJournal of Ocular Pharmacology and Therapeutics 2009; 25: 141-144
Purpose: To investigate the effect of systemic acetazolamide on ocular pulse amplitude (OPA) and on intraocular pressure (IOP). Methods: We determined OPA, IOP, mean arterial blood pressure and heart rate (HR) in 17 patients suffering from hypertensive primary open-angle glaucoma (htPOAG) and 22 healthy controls. Measurements were taken before and 2 h after oral intake of 500 mg of acetazolamide. Results: Mean OPA decreased 20.24% (SEM 2.95%) from 2.76 mmHg (SEM 0.16 mmHg) to 2.14 mmHg (SEM 0.13 mmHg) 2 h after oral administration of 500-mg acetazolamide. IOP dropped by 2.98 mmHg (SEM 0.28 mmHg), corresponding to a 17.19% (SEM 1.56%) reduction. The decrease in IOP correlated with the decrease of OPA (r(2) = 0.4, P < 0.0001). Conclusions: Ocular pulse amplitude measurements are influenced by oral administration of acetazolamide. There was a decrease in the pulsatile component of choroidal blood flow and in IOP in both htPOAG and healthy controls. This needs to be taken into account for measurement of OPA with dynamic contour tonometry.
M. S. Zinkernagel. Centre for Ophthalmology and Visual Sciences (COVS), Lions Eye Institute, 2 Verdun Street, Nedlands, WA 6008, Australia. m.zinkernagel@gmail.com
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
11.5.1 Systemic (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)