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Abstract #24717 Published in IGR 11-4
Effects of transplantation of amniotic membrane on synulosis of the filtering area following resemble trabeculectomy in rabbit eyes
Li Y-I; Li J-MJournal of Dalian Medical University 2009; 31: 295-298
[Objective] To explore the effects of transplantation of amniotic membrane on synulosis in the filtering area following resemble trabeculectomy. [Methods] Thirty-six white anosia rabbits (72 eyes) were divided into three groups randomly: the trabeculectomy with transplantation of amniotic membrane(A), the trabeculectomy with treatment of mitomycin (B) and trabeculectomy(C). Intraocular pressure(IOP), filtration blebs, synulosis and the expression bFGF in the filtration area tissue were examined at different time after the surgery. [Results] In the group A and B, the cells showing positive reaction to bFGF were few and positive substance distributed sparsely in the filtering area at the 14th day after operation. Few fibroblasts and fibrosis cells were seen. But in the group C, a lot of positive cells for bEGF were seen in the filtering area at the 3rd day; the number of these cells reached to the peak at the 7th day. No proliferation of fibroblast was found instead of the fibrosis completely on the 14th day. The proportion of functional filtation blebs for group A, B and C were 95.8%, 100% and 79.1%, respectively (P < 0.05). The range of IOP for group A and B was stable between 13 and 21 millimetres of mercury, lower than that before operation between 18 and 23 millimetres of mercury (P < 0.05). [Conclusion] Transplantation of amniotic membrane may inhibit the activity of fibroblast after trabeculectomy can be restrained. LA: Chinese
Y.-I. Li. Department of Ophthalmology, Second Hospital of Dalian, Dalian 116011, China. lyl303173@126.com
Classification:
12.8.1 Without tube implant (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
