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1 General aspects (0)   1.1 Epidemiology (7)   1.2 Population genetics (0)   1.3 Pathogenesis (4)   1.4 Quality of life (8)   1.5 Glaucomas as cause of blindness (5)   1.6 Prevention and screening (8) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (6)   2.2 Cornea (14)   2.3 Sclera (3)   2.4 Anterior chamber angle (3)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (6)     2.5.2 Schlemms canal (2)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (4)       2.6.2.2 Uveoscleral (1)     2.6.3 Compostion (0)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (3)   2.9 Ciliary body (6)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (0)   2.13 Retina and retinal nerve fibre layer (21)   2.14 Optic disc (17)   2.15 Optic nerve (5)   2.16 Chiasma and retrochiasmal central nervous system (4)   2.17 Stem cells (1)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (1)   3.2 Electron microscopy (2)   3.3 Immunohistochemistry (3)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (2)     3.4.2 Gene studies (16)   3.5 Molecular biology incl. 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associated with intraocular tumors (1)     9.4.9 Glaucomas associated with elevated episcleral venous pressure (1)       9.4.10 Glaucomas associated with hemorrhage (2)     9.4.11 Glaucomas following intraocular surgery (0)       9.4.11.1 Ciliary block (malignant) glaucoma (2)       9.4.11.2 Glaucomas in aphakia and pseudophakia (3)       9.4.11.3 Epithelial, fibrous, and endothelial proliferation (0)       9.4.11.4 Glaucomas associated with corneal surgery (2)       9.4.11.5 Glaucomas associated with vitreoretinal surgery (4)     9.4.15 Glaucoma in relation to systemic disease (17)     9.4.20 Other (0) 10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy (3) 11 Medical treatment (0)   11.1 General management, indication (9)   11.2 Cholinergic drugs (2)   11.3 Adrenergic drugs (0)     11.3.1 Epinephrine (0)     11.3.2 Thymoxamine, dapiprazole (0)     11.3.3 Apraclonidine, brimonidine (2)     11.3.4 Betablocker (6)     11.3.5 Other (0)   11.4 Prostaglandins 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Miscellaneous (31)

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Abstract #24747 Published in IGR 11-4

Construction and appraisal of chronic ocular hypertension glaucoma model of rats

Sha Q; Nie Q-Z; Zhang Y; Gao D-W
International Journal of Ophthalmology 2009; 9: 1463-1465

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AIM: The establishment of chronic ocular hypertension surgery glaucoma animal model for the study of the pathogenesis, treatment and protection of these three aspects of the optic nerve is particularly necessary. METHODS: Superficial burning three episcleral veins, and surgery combined with conjunctival flap under the Baptist has the mitomycin C 0.2g/L gel sponge, to block rat aqueous outflow of the eye can induce by intraocular pressure(IOP), the establishment of rat model of chronic high intraocular pressure. After surgery 2 hours, 1 day, 3, 7, 14, 28, 56 days, 5 rats were killed, blank control group, also killed 5 rats; Eyeballs were removed for light microscopy, retinal eye patterns observation and measurement of retinal thickness in order to study the IOP, retinal ganglion cells (RGC) and optic nerve injury characteristics. RESULTS: The rats with sham surgery eye eyes, eye control of postoperative intraocular pressure at different time points of comparison there was a significant difference (P < 0.01). CONCLUSION: Rats with chronic ocular hypertension model is simple, reproducible and high rate into a mold, high intraocular pressure may maintain stability for a long time. Chronic high intraocular pressure of the final results will lead to the thinning of the retina and atrophy. LA: Chinese

Y. Zhang. Department of Ophtahlmology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China. sq_1972@126.com

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Classification:

5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)

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