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Abstract #24760 Published in IGR 11-4
Brinzolamide/timolol fixed combination for open-angle glaucoma and ocular hypertension
Hollo GExpert Review of Ophthalmology 2009; 4: 129-133
The brinzolamide/timolol fixed combination contains brinzolamide 1% and timolol maleate 0.5% in ophthalmic suspension produced for twice-daily application to reduce elevated intraocular pressure in open-angle glaucoma and ocular hypertension. This fixed combination was recently approved by the European Medicines Agency, in December 2008. The brimzolamide/timolol fixed combination provides an approximately 30-33% intraocular pressure reduction from the untreated baseline of 25-27 mmHg, thus is more potent than any of its ingredients alone and is similarly effective but better tolerated than the dorzolamide/timolol fixed combination, which consists of molecules from the same drug classes. The fixed combination of brinzolamide and timolol can be used as a separate therapy, but due to the additivity of its ingredients to drugs belonging to other classes, it may also be administered in combination with other intraocular pressure-lowering molecules, most importantly topical prostaglandin analogues.
G. Hollo. Department of Ophthalmology, Semmelweis University, Tomo u. 25-29, 1083 Budapest, Hungary. hg@szem1.sote.hu
Classification:
11.13.2 Betablocker and carbon anhydrase inhibitor (Part of: 11 Medical treatment > 11.13 Combination therapy)
