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Abstract #24774 Published in IGR 11-4
Long-term clinical complications in Vogt-Koyanagi-Harada disease: A matched case-control analysis of retinal thickness measurements using optical coherence tomography
Supasilkanok S; Laksanaphuk P; Varadisai A; Pasadhika S; Chawasirikunthol J; Tulvatana WAsian Biomedicine 2009; 3: 309-312
To study long-term clinical complications of Vogt-Koyanagi-Harada (VKH) disease and to compare retinal thickness using optical coherence tomography (OCT) in VKH patients with age- and gender-matched controls. Methods: Patients diagnosed with VKH for more than 6 months were identified from hospital files. Clinical presentation and clinical course were studied. OCT of the retina was performed in these patients during the most recent follow-up examination to compare with age- and gender-matched controls recruited from outpatient clinics. Results: Eighteen VKH patients (4 male, 14 female) were studied. Mean age at diagnosis was 35.1 years (SD 13.0). Mean age at last follow up was 40.8 years (SD=15.1). Median time to last follow-up was 5.2 years (interquartile range=1.7-8.1). Thirty eyes (83%) developed at least one complication, including recurrent anterior uveitis in 16 eyes (44%), glaucoma in 16 eyes (44%), cataract in 11 eyes (31%), pseudophakia in 10 eyes (28%), and aphakia in one eye (3%). Two patients were blind in one eye. Tinnitus persisted longer than 6 months in two patients. Cutaneous complications such as alopecia, vitiligo, and poliosis were present in seven patients (39%). Mean central retinal thickness was 190.1 microns (SD 61.5), comparing with 181.5 microns (SD=47.9) in controls, p=0.43. Mean retinal thickness at superior inner macula was 250.6 microns (SD=65.5), comparing with 259.0 microns (SD=66.0) in controls, p=0.15. Conclusion: Most of the VKH patients develop long-term clinical complications. The retinal thickness, measured by OCT, in VKH patients is not significantly different from that of age- and gender-matched controls.
W. Tulvatana. Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. waseetulvatana@gmail.com
Classification:
9.4.6 Glaucomas associated with inflammation, uveitis (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
2.15 Optic nerve (Part of: 2 Anatomical structures in glaucoma)
