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Abstract #24954 Published in IGR 11-4
Topiramate and asymptomatic ocular angle narrowing: a prospective pilot study
Leung DYL; Leung H; Baig N; Kwan P; Kwong YYK; Wong KS; Lam DSCEye 2009; 23: 2079-2081
Purpose: To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM). Methods: Chinese patients aged 18–75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate. Results: In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 m, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness. Conclusion: Short-term use of topiramate does not induce asymptomatic angle narrowing.
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong
Classification:
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
9.3.10 Other (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
