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Abstract #25208 Published in IGR 12-1
Replication of a Glaucoma Candidate Gene on 5q22.1 for Intraocular Pressure in Mongolian Populations: The GENDISCAN Project
Lee MK; Woo SJ; Kim JI; Cho SI; Kim H; Sung J; Seo JS; Kim DMInvestigative Ophthalmology and Visual Science 2010; 51: 1335-1340
Purpose. Glaucoma is the second most frequent cause of visual impairment worldwide. Elevated intraocular pressure (IOP) causes glaucomatous optic nerve damage, especially in the primary open-angle glaucoma (POAG) subtype. As most previous studies on IOP genetics were analyses of glaucomatous families, a study of general pedigrees will provide additional information on genetic etiology. Methods. This work was part of the GENDISCAN study (Gene Discovery for Complex Traits in Isolated Large Families of Asians of the Northeast), which recruited families from population isolates in Mongolia. IOP (obtained by a noncontact method), epidemiologic, and clinical information were collected from 1451 healthy individuals of 142 families. From these individuals, 390 genome-wide short tandem repeat markers were genotyped. Variance component-based linkage analysis was applied to pursue candidate loci explaining IOP variation. Results. The mean IOP was 13.6 mm Hg in the men and 13.7 mm Hg in the women, inversely associated with aging (beta = -0.05; P
Complex Disease Genetic Epidemiology Branch, Department of Epidemiology, Graduate School of Public Health and Institute of Environment and Health, and.
Classification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
