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Abstract #25224 Published in IGR 12-1

Comparison of real-time intraocular pressure during laser in situ keratomileusis and epithelial laser in situ keratomileusis in porcine eyes

Hernández-Verdejo JL; de Benito-Llopis L; Teus MA
Journal of Cataract and Refractive Surgery 2010; 36: 477-482

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PURPOSE: To compare real-time intraocular pressure (IOP) between laser in situ keratomileusis (LASIK) and epithelial LASIK (epi-LASIK) in porcine eyes during flap creation using a microkeratome or an epikeratome, respectively. SETTING: Vissum Madrid, Madrid, Spain. METHODS: In this prospective study, a Moria microkeratome was used in 1 eye (LASIK group) and an Epi-K epikeratome in the other eye (epi-LASIK group) to create a lamellar corneal flap and an epithelial flap, respectively, in freshly enucleated porcine eyes. The IOP changes during the procedures were recorded by direct cannulation using a reusable blood pressure transducer connected to the anterior chamber. RESULTS: Each group comprised 17 eyes. In the LASIK group, the mean IOP was 113.65 mm Hg +/- 10.78 (SD) during suctioning and 112.35 +/- 11.51 mm Hg during cutting phases. The mean duration of the phases was 9.00 +/- 1.46 seconds and 6.06 +/- 1.14 seconds, respectively. In the epi-LASIK group, the mean IOP was 92.57 +/- 20.86 mm Hg during suctioning, 82.09 +/- 20 mm Hg during cutting, and 67.28 +/- 13.49 during low vacuum. The mean duration of the phases was 25.88 +/- 1.96 seconds, 33.82 +/- 2.81 seconds, and 29.71 +/- 3.29 seconds, respectively. The IOP values were significantly different between the 2 groups (all comparisons P<.05). CONCLUSION: Real-time IOP measured during suctioning and flap creation by direct cannulation of the anterior chamber in freshly enucleated porcine eyes showed a significant increase in IOP during LASIK and epi-LASIK; the increase was lower in the epi-LASIK group.

From Vissum Madrid (Hernández-Verdejo, Benito-Llopis, Teus), Universidad Complutense de Madrid (Hernández-Verdejo), Universidad de Alcalá (Teus), Alcalá de Henares, Madrid, Spain.

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Classification:

9.4.11.4 Glaucomas associated with corneal surgery (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.11 Glaucomas following intraocular surgery)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)

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