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Abstract #25315 Published in IGR 12-1
Combination brain-derived neurotrophic factor and LINGO-1 fusion protein promote long-term survival to retinal ganglion cells after ocular hypertension
Fu Q -L; Yip H K; Li X; Shao Z; Wu W; Mi S; So K -FNeuroscience Research 2009; 162: 375-382
Glaucoma is a progressive neuropathy characterized by loss of vision as a result of retinal ganglion cell (RGC) death. Brain-derived neurotrophic factor (BDNF) is well known to transiently delay RGC death in ocular hypertensive eyes. Using a rat ocular hypertension model, we identified that BDNF alone shows slight neuroprotection to RGCs after a long-term progress of 4 weeks following the induction of ocular hypertension. However, combination of BDNF and LINGO-1-Fc prevents RGC death in the same condition. We further identified that LINGO-1 was co-expressed with TrkB in the RGCs and BDNF combined with LINGO-1-Fc activated more TrkB in the injured retina compared to BDNF alone. These results indicate that combination of BDNF and LINGO-1-Fc provides long-term protection for RGCs in a chronic ocular hypertension model.
Q.-L. Fu. First Affiliated Hospital, Sun Yat-Sen University, China.
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
