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Abstract #25393 Published in IGR 12-1
The effect of forskolin ophthalmic inserts on intraocular pressure in rabbit eyes
Wagh V D; Wagh K V; Inamdar B; Samanta M KInternational Journal of Pharmacy and Pharmaceutical Sciences 2009; 146-155
Forskolin, a diterpene obtained from natural roots of Coleus forskohlii (wild) Briq. (family: Lamiaceae), reduces Intra Ocular Pressure by 23-28%, which is a desirable feature for an antiglaucoma therapy. Ophthalmic Inserts of forskolin extract (OIE) and pure forskolin (OIF) were prepared as matrix controlled delivery with the aim of achieving once a day administration. Ocular safety studies by draize test, pharmacodynamic efficacy by schiontz tonometry and precorneal residence by HPTLC technique were conducted in 30 New Zealand albino rabbits to investigate their safety for ocular administration. Obtained results concluded, that the Ophthalmic Insert Drug Delivery System (OIDDS) for forskolin shown a significant reduction in Intraocular Pressure up to 24 hours and an increased corneal residence time up to 12 hours with sustained therapeutic action which is a desirable feature for an ideal antiglaucoma agent.
V. D. Wagh. Department of Pharmaceutics, Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rouza Bagh, Aurangabad-431001. M.S, India. vijaydwagh@gmail.com
Classification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
