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Miscellaneous (8)

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Abstract #25401 Published in IGR 12-1

The prevention effect of pyrrolidine dithiocarbamate against scarring of filtering bleb in rats

Li X; Ma J; Wang N
Chinese Ophthalmic Research 2009; 27: 858-862

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Objective: Pyrrolidine dithio-carbamate( PDTC), a NF-(kappa)B inhibitor, was confirmed to be a inhibitor of nuclear factor kappa B(NF-(kappa)B) and can induce apoptosis and suppress the secretion of inflammatory factors. Our previous study has demonstrated its inhibiting effect on Tenon's capsule fibroblasts(TCFS) in SD rats. The purpose of this study was to evaluate the effect of PDTC on the prevention of filtering bleb scarring after anti-glaucoma surgery. Methods: Filtration surgery was performed on both eyes of twenty-four female SD rats and divided into three groups, including negative control group, PDTC group and mitomycin C(MMC) group. 1 mol/L PDTC and 0.4 mg/mL MMC was topically utilized for 5 minutes during the operations in the latter two groups respectively. The postoperative bleb appearance and complications were clinically observed in everyday. The other 9 SD rats were used for the monocular filtration surgery and grouped according to mentioned above. The SD rats were killed and the operative eyes were enucleated for HE staining on day 7 after surgery. Results: Bleb survival was (13.16 (plus or minus) 2.588) days in PDTC group and (13.75 (plus or minus) 2.352) days in MMC group, showing a longer survival time than control group(10.06 (plus or minus) 1.806) days (P <0.01). There was no significant difference in survival time of filtering bleb between PDTC group and MMC group (P =0.442). Postoperative blebs of PDTC group were pallor on the first few days. New vessels grow toward filtering bleb on day 4-7 after surgery in PDTC group and day 3-5 in MMC group. Cornea opacity was observed in three eyes in MMC group and one eye in PDTC group. Pathological morphology examination demonstrated that more fibroblasts and collagen fibers were seen in control group compared with PDTC group and MMC group on day 7 after surgery. Conclusion: PDTC has a good effectiveness in preventing filtering bleb scarring formation and decreasing complications, showing a similar outcome to MMC. Therefore, PDTC could be a new anti-scar drug in ophthalmology. LA: Chinese

X. Li. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

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Classification:

12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)

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