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Abstract #25422 Published in IGR 12-1
Intravitreal bevacizumab for neovascular glaucoma
Vasudev D; Blair M P; Galasso J; Kapur R; Vajaranant TJournal of Ocular Pharmacology and Therapeutics 2009; 25: 453-458
Purpose: To report 6-month and 1 year outcomes of eyes treated for neovascular glaucoma (NVG) with intravitreal bevacizumab injection and panretinal laser (PRP) compared to those receiving PRP alone. Design: retrospective, consecutive case series. Methods: Charts of patients with NVG from retinal ischemia and at least 6 months of follow-up were reviewed. Patients were treated with one injection of 1.25 mg intravitreal bevacizumab followed by PRP or with PRP alone. The primary outcome was the long-term angle anatomy. Secondary measures included intraocular pressure (IOP), visual acuity, patient compliance, and control of systemic diseases. Results: Fourteen eyes of 12 patients treated with bevacizumab and PRP and 15 eyes of 11 patients treated with PRP alone were included in the study. Mean sectors of open angle at baseline was 1.31 in the bevacizumab group and 1.47 in the retinal ablation group (P = 0.73). Mean sectors of open angle was 2.14 and 1.18 in the bevacizumab and retinal ablation groups, respectively (P < 0.05) at 6-month follow-up, and 2.27 and 1.18, respectively (P < 0.05) at 1-year follow-up. Mean baseline IOP was 32.3 mmHg ((plus or minus)14.8) in the bevacizumab group and 31.8 mmHg ((plus or minus)13) in the PRP group (P = 0.75). At 6-month follow-up, the mean IOP was 18.28 mmHg ((plus or minus)10) in the bevacizumab group and 23.33 mmHg ((plus or minus)14.6) in the PRP group (P = 0.05), and 19.12 mmHg ((plus or minus)6.8) and 26.2 mmHg ((plus or minus)18) (P = 0.1), respectively at 1-year follow-up. Nineteen patients were judged to be noncompliant, 10 had uncontrolled diabetes and 7 had uncontrolled hypertension. Conclusions: This study documents better long-term preservation of open angle and IOP control in eyes receiving bevacizumab along with PRP. We stress that NVG is still associated with poor visual acuity outcomes.
M. P. Blair. University of Illinois, Eye and Ear Infi Rmary, 1855 W Taylor Street, Chicago, IL 60612, United States. Mblair2@uic.edu
Classification:
9.4.5.1 Neovascular glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
