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Abstract #25426 Published in IGR 12-1
Fixed-combination brimonidine/timolol as adjunctive therapy to a prostaglandin analog: A 3-month, open-label, replacement study in glaucoma patients
Nguyen Q H; Earl MJournal of Ocular Pharmacology and Therapeutics 2009; 25: 541-544
Purpose: To evaluate intraocular pressure (IOP) and ocular allergy after replacement of 1 of 2 adjunctive therapy regimens (fixed-combination dorzolamide/timolol or dorzolamide/timolol plus brimonidine) with fixed-combination brimonidine/timolol in glaucoma patients treated with ongoing prostaglandin analog (PGA) therapy. Methods: This prospective, nonrandomized, open-label study involved patients on dorzolamide 2/timolol 0.5 and a PGA who needed lower IOP and patients on brimonidine, dorzolamide 2/timolol 0.5, and a PGA who wanted to simplify their treatment regimens. After the baseline evaluation, patients were continued on the PGA and their other IOP-lowering medications were replaced with brimonidine 0.2/timolol 0.5. IOP was measured at baseline and months 1 and 3. Results: In patients who replaced dorzolamide/timolol with brimonidine/timolol (n = 45), the mean (SD) IOP was 15.9 (1.4) mm Hg at baseline, 13.3 (0.9) mm Hg after 1 month (P < 0.001 vs. baseline), and 13.3 (1.0) mm Hg after 3 months (P < 0.001 vs. baseline). In patients who replaced both brimonidine and dorzolamide/timolol with brimonidine/timolol (n = 15), the mean (SD) IOP was 15.9 (5.2) mm Hg at baseline, 13.8 (1.8) mm Hg after 1 month (P = 0.053 vs. baseline), and 13.8 (1.4) mm Hg after 3 months (P = 0.079 vs. baseline). Allergy was reported in 5 patients previously treated with dorzolamide/timolol and 1 patient previously treated with brimonidine plus dorzolamide/timolol. Conclusions: For patients on multiple-drug therapy including a PGA, replacement of dorzolamide/timolol with brimonidine/timolol may help achieve a lower IOP, while replacement of brimonidine plus dorzolamide/timolol with brimonidine/timolol may help achieve as low an IOP with fewer medications.
Q. H. Nguyen. Division of Ophthalmology, Scripps Clinic, MS 214, 10666 N. Torrey Pine Road, San Diego, CA 92037, United States. Nguyen.Quang@scrippshealth.org
Classification:
11.13.3 Betablocker and brimonidine (Part of: 11 Medical treatment > 11.13 Combination therapy)
11.4 Prostaglandins (Part of: 11 Medical treatment)
