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Abstract #25451 Published in IGR 12-1
New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients
Kourkoutas D; Georgopoulos G; Maragos A; Apostolakis I; Tsekouras G; Karanasiou I S; Papaconstantinou D; Iliakis E; Moschos MClinical Ophthalmology 2009; 3: 313-323
Purpose: In this paper a new nonlinear multivariable regression method is presented in order to investigate the relationship between the central corneal thickness (CCT) and the Heidelberg Retina Tomograph (HRTII) optic nerve head (ONH) topographic measurements, in patients with established glaucoma. Methods: Forty nine eyes of 49 patients with glaucoma were included in this study. Inclusion criteria were patients with (a) HRT II ONH imaging of good quality (SD < 30 (mu)m), (b) reliable Humphrey visual field tests (30-2 program), and (c) bilateral CCT measurements with ultrasonic contact pachymetry. Patients were classified as glaucomatous based on visual field and/or ONH damage. The relationship between CCT and topographic parameters was analyzed by using the new nonlinear multivariable regression model. Results: In the entire group, CCT was 549.78 (plus or minus) 33.08 (mu)m (range: 484-636 (mu)m); intraocular pressure (IOP) was 16.4 (plus or minus) 2.67 mmHg (range: 11-23 mmHg); MD was -3.80 (plus or minus) 4.97 dB (range: 4.04 - [-20.4] dB); refraction was -0.78 (plus or minus) 2.46 D (range: -6.0 D to +3.0 D). The new nonlinear multivariable regression model we used indicated that CCT was significantly related (R(2) = 0.227, p < 0.01) with rim volume nasally and type of diagnosis. Conclusions: By using the new nonlinear multivariable regression model, in patients with established glaucoma, our data showed that there is a statistically significant correlation between CCT and HRTII ONH structural measurements, in glaucoma patients.
D. Kourkoutas. Department of Ophthalmology, 417 Hellenic Army Shared Fund Hospital, 10-12 M Petraki Street, 11521, Athens, Greece. d_kourkoutas@hotmail.com
Classification:
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
