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Abstract #25482 Published in IGR 12-1
The effects of antiglaucomatous topical medications on retinal ganglion cell apoptosis
Karakucuk S; Yuce Y; Ulusal H; Oner A; Gumus K; Mirza E; Mujdeci MErciyes Tip Dergisi 2009; 31: 310-317
Purpose: It was aimed to determine the effects of topically applied latanoprost, brimonidine, dorzolamide and betoxolol on ganglion cell apoptosis in an experimental rat model. Material and Methods: Intraocular pressure (IOP) was increased by episcleral vein cauterization in 36 Wistar male albino rats. Rats were divided into 5 sub-groups as follows: Group 1 received no medication (n=6), group 2 received latanoprost treatment once daily (n=8), group 3 received brimonidine treatment twice daily (n=6), group 4 receieved dorzolamide treatment 3 times daily (n=9), and group 5 received betoxolol treatment twice daily (n=7). IOP was recorded before and immediately after the cauterization, on the 1st, 2nd, 3rd and 4th weeks. All eyes were enucleated after four weeks after medication. Apoptosis was determined using the TUNNEL method. Results: IOP was observed as increased after cauterization. The eyes were found to have higher rate of apoptosis in group-1. There was not a statistically significant difference among the groups in terms of rate of apoptosis. Conclusion: In an experimental rat model of glaucoma, latanoprost, brimonidine, dorzolamide and betoxolol was found as equally effective in reducing IOP and these agents similarly lowered the rate of ganglion cell apoptosis when compared to group 1. LA: Turkish
S. Karakucuk. Department of Ophthalmology, Faculty of Medicine, Erciyes University, . sarperkarakucuk@gmail.com
Classification:
11.1 General management, indication (Part of: 11 Medical treatment)
11.8 Neuroprotection (Part of: 11 Medical treatment)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)