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Abstract #25572 Published in IGR 12-1
Experimental study on the protective effects of qingguangan granule on optic nerve axons in rabbit eyes with acute ocular hypertension
Zhao H -B; Peng Q -H; Wu Q -L; Zeng Z -CInternational Journal of Ophthalmology 2009; 9: 2318-2321
AIM: To observe the protective effects of qingguangan granule (QGAG) on optic nerve axons and retinal ganglion cells in rabbit eyes with acute ocular hypertension. METHODS: Fourty-eight rabbits were divided into two groups: treatment group and control group(24 in each). The acute ocular hypertension (60mmHg) models were established by forcing perfusion of normal saline solution into the anterior chamber, the other eye in experimental group which was maintained at basic intraocular pressure by the same method was regarded as normal control. The stomach in each group was irrigated for 14 days. The rabbits were killed 7 and 14 days after modeling respectively. The levels of the glutamic acid and NO in retina was measured, and the pathologic changes were observed. RESULTS: After7 days, the glutamic acid and NO levels had significant difference between each group (P < 0.01), and the levels in the treatment group and experimental group were significantly higher than that in normal control group; the differences were significant (P < 0.05, P < 0.01). But that in the treatment group was significantly lower than those in experimental group (P < 0.01). After 14 days, the glutamic acid and NO levels in treatment group were close to that of the normal control group. However, the levels in the experimental group were significantly higher than those in normal control group (P < 0.05, P < 0.01). There were significant differen-ces in two weeks between the treatment group and experimental group (P < 0.05). Electron microscope result indicated that, for treatment group, optic nerve axons swelled less gently, mitochondria in optic nerve axons was clear and more, and the degree of damaged retina ganglion cells was lower compared with experimental group. CONCLUSION: QGAG can ameliorate retina microcirculation, promote the axoplasmic transport of optic nerve, accelerate NO and glutaminic acid removal in rabbits retina with acute ocular hypertension. It has the protective function for the optic nerve axons and the retinal ganglion cells. LA: Chinese
Q.-H. Peng. Key Discipline of Ophthalmology, Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, China. pqhz_520@126.com
Classification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
