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Abstract #25718 Published in IGR 12-2
Prevalence of ocular surface complaints in patients with glaucoma using topical intraocular pressure-lowering medications
Fechtner RD; Godfrey DG; Budenz D; Stewart JA; Stewart WC; Jasek MCCornea 2010; 29: 618-621
PURPOSE: To determine the prevalence of ocular surface disease (OSD) in patients with glaucoma using topical intraocular pressure (IOP) -lowering therapy. METHODS: This prospective observational study enrolled patients with primary open-angle glaucoma or ocular hypertension who were on a topical IOP-lowering medication regimen. Enrolled patients completed the ocular surface disease index (OSDI) and OSDI scores (0-100, with 0 representing no symptoms) were calculated for each patient. Medical history, demographics, and concomitant medication information were also collected. RESULTS: Overall, 630 patients from 10 sites participated. Of these, 305 patients (48.4%) had an OSDI score indicating either mild (n = 134, 21.3%), moderate (n = 84, 13.3%), or severe (n = 87, 13.8%) OSD symptoms. OSDI scores were significantly different between patients with and without a prior diagnosis of dry eye syndrome (25.2 (plus or minus) 15.4 vs 15.4 (plus or minus) 15.8, respectively; P = 0.0036) and between patients who did and did not use artificial tears at the time of study participation (23.0 (plus or minus) 15.6 vs 15.3 (plus or minus) 15.8, respectively; P = 0.0046). Mean OSDI scores varied significantly with the number of topical IOP-lowering medications used, with higher (more severe) OSDI scores in patients using multiple IOP-lowering medications. Specifically, patients on a single medication had a mean OSDI score of 12.9 (plus or minus) 13.1, which was significantly lower than those of patients on 2 (16.7 (plus or minus) 17.0; P = 0.007) or 3 medications (19.4 (plus or minus) 18.1; P = 0.0001). CONCLUSIONS: OSD is prevalent among medically treated patients with glaucoma. The severity of OSD symptoms is positively correlated to the number of IOP-lowering medications used.
R. D. Fechtner.
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
2.1 Conjunctiva (Part of: 2 Anatomical structures in glaucoma)
11.1 General management, indication (Part of: 11 Medical treatment)