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Abstract #25749 Published in IGR 12-2
Relationships between glaucoma, arterial stiffness and inflammatory process
Siasou G; Tousoulis D; Moschos M; Siasos G; Gialafos E; Oikonomou E; Plastiras A; Zaromitidou M; Zisimos K; Verveniotis AJournal of the American College of Cardiology 2010; 55: A159.E1494.
Background: Reduced ocular blood flow, mostly caused by vascular dysregulation, plays a pivotal role in the pathogenesis of primary open-angle glaucoma (POAG). Glaucoma is also associated with peripheral vascular endothelial dysfunction. However the effect of POAG on vascular function and the inflammatory process is unknown. Therefore in the present study we evaluate arterial stiffness and inflammatory process in patients with POAG. Methods: We enrolled 38 patients with POAG and 32 healthy age- and sex- matched normal control subjects, all of whom had no medical history of cardiovascular disease or cardiovascular risk factors. All subjects underwent a complete ophthalmological examination. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections. Circulating levels of soluble interleukin -6 (IL-6) and soluble intercellular cells adhesion molecule (s-ICAM-1) were measured by ELISA. Results: PWV values differed significantly in POAG patients (8.86(plus or minus)0.33m/s) compared with controls (7.56(plus or minus)0.33m/s) (P< 0.01). Also AIx values were 27.68(plus or minus)1.01% in the POAG group and 22.85(plus or minus)2.08% in the control group (P<0.05). Moreover, we found a significant increase in the release of IL-6 (2.54(plus or minus)0.36 pgr/ml) and s-ICAM-1 (540.21(plus or minus)41.71 ngr/ml) in POAG patients compared with controls (IL-6: 1.54(plus or minus)0.17 pgr/ml, s-ICAM-1: 421.05(plus or minus)48.84 ngr/ml) (P<0.05 for both), indicating an elevated inflammatory status in POAG patients. Finally a positive correlation was noted, only in the POAG group, between PWV and IL-6 (p<0.05, r=0.367). Conclusion: These findings indicate that primary open angle glaucoma is a systematic disorder which affects vascular function and increases inflammatory process.
G. Siasou. Hippocration General Hospital of Athens, Athens Univercity Medical School, Athens, Greece.
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
1.3 Pathogenesis (Part of: 1 General aspects)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
