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1 General aspects (0)   1.1 Epidemiology (6)   1.2 Population genetics (4)   1.3 Pathogenesis (8)   1.4 Quality of life (5)   1.5 Glaucomas as cause of blindness (4)   1.6 Prevention and screening (9) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (3)   2.2 Cornea (19)   2.3 Sclera (2)   2.4 Anterior chamber angle (6)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (10)     2.5.2 Schlemms canal (2)     2.5.3 Scleral outlet channels (1)   2.6 Aqueous humor dynamics (1)     2.6.1 Production (1)     2.6.2 Outflow (1)       2.6.2.1 Trabecular meshwork (3)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (6)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (0)   2.9 Ciliary body (2)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (4)   2.13 Retina and retinal nerve fibre layer (23)   2.14 Optic disc (20)   2.15 Optic nerve (2)   2.16 Chiasma and retrochiasmal central nervous system (4)   2.17 Stem cells (4)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (1)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (2)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (29)   3.5 Molecular biology incl. 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Miscellaneous (19)

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Abstract #25809 Published in IGR 12-2

Expression of ClC-2 Chloride channels in rat trabecular meshwork

Wang J-X; Wang S-M; Lju H-Y
Chinese Journal of Biologicals 2010; 23: 274-276

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Objective To investigate the expression of ClC-2 chloride channels in rat trabecular meshwork as well as possible role of ClC-2 in onset mechanism of glaucoma. Methods Rat model of chronic high intraocular pressure was established by injecting sodium hyaluronate into anterior chamber. The trabecular meshwork tissues of normal and model rats were isolated, in which the transcription level of ClC-2 mRNA was determined by RT-PCR, and the expression level of ClC-2 protein by immunohistochemical method. Results The transcription of ClC-2 mRNA and expression of ClC-2 protein were observed in the trabecular meshwork tissues of both normal and model rats, while the transcription and expression levels in model rats were lower than those in normal rats. Conclusion The expression of ClC-2 chloride channels was proved in rat trabecular meshwork, which was influenced by some pathological factors of trabecular meshwork. LA: Chinese

J.-X. Wang. Second Hospital, Jilin University, Changchun 130041, China. zhengyajuan124@yahoo.com.cn

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Classification:

2.5.1 Trabecular meshwork (Part of: 2 Anatomical structures in glaucoma > 2.5 Meshwork)
3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)

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