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Abstract #25817 Published in IGR 12-2
Intraocular hypotensive effect and action on aqueous humor dynamics of (alpha)-ergocryptine in ocular normotensive and in (alpha)-chymotrypsin-induced ocular hypertensive rabbits
Puras G; Garcia VB; Rivera GRevista Mexicana de Ciencias Farmaceuticas 2009; 40: 22-29
The aim of the present work was to compare the effect of (alpha)-ergocryptine on the intraocular pressure (IOP) and aqueous humor (AH) dynamics in ocular normotensive and (alpha)-chymotrypsin-induced ocular hypertensive rabbits. Our data suggest that (alpha)-ergocryptine decreases both tonographic outflow facility and, to a greater extent, AH inflow, which explains the final effect in ocular normotensive and in (alpha)-chymotrypsin-induced ocular hypertensive rabbits. Reductions in AH inflow observed after topical application of (alpha)-ergocryptine in (alpha)-chymotrypsin-induced ocular hypertensive rabbits can only be explained by a marked inhibition of active secretion of AH, since processes involved in AH formation, may be probably altered after (alpha)-chymotrypsin injection.
G. Rivera. Departamento de Farmacia y Quimica Medicina, UAM Reynosa-Aztlan, Universidad Autonoma de Tamaulipas, Calle 16 y Lago de Chapala, s/n, 88740 Reynosa, Mexico. gildardors@hotmail.com
Classification:
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
2.6 Aqueous humor dynamics (Part of: 2 Anatomical structures in glaucoma)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)